Children are our future. Pediatric diseases often require personalized medicine to be treated.
Our Center aims to provide an answer to all those in need, to families, to children.
To offer a new opportunity and a cure.
WHAT THE FIORINA GROUP DOES
The Fiorina Group has been working on type 1 diabetes mellitus for over 15 years.
In particular, it has published several scientific papers on the study of immune response and its modulation in patients with diabetes, on acute and chronic complications of type 1 diabetes, on the role of stem cells in diabetes, on islet transplantation in murine preclinical models and in clinical studies in patients.
The interest has expanded to the immunometabolic sphere and type 2 diabetes with the use of an increasingly cutting-edge multiomic approach and a growing interest in the development of new therapeutics to bring to the patient’s bedside.
The projects developed by the group have a typically translational approach, in which basic research often meets clinical application, making the results obtained of extreme interest to the scientific community.
CURRENTLY THE GROUP FOCUSES ITS INTEREST ON THE FOLLOWING TOPICS:
- Development of a vaccine therapy for type 1 diabetes
- Study of mechanisms that preserve beta cell mass in type 1 diabetes
- Identification of new therapeutic targets for the treatment of cardiovascular diseases in type 1 diabetes
- New mechanisms underlying diabetic nephropathy
- New factors involved in tissue fibrosis during diabetes
- Immunological role of the GLP-1 receptor pathway
- Characterization and targeting of regulatory B lymphocytes in type 1 diabetes
SERVICE OFFERED
The Fiorina Group, leveraging its extensive experience in the study of type 1 diabetes, offers the following services:
- Basic immuno-phenotypic characterization of immune system cells (T lymphocytes, B lymphocytes, and macrophages)
- Functional characterization of immune response (quantification of immune response to stimuli, compounds, proteins, peptides through Elispot assay)
- Transcriptome profiling through array
- Cytokines profiling, Analysis of circulating soluble factors (Bio-Plex 200)
- Proteomics, metabolomics, and lipidomics outsourcing
- Expression studies through confocal microscopy
- Discovery of potency assays for clinical development of new therapeutics
TEAM
The team consists of Professor Paolo Fiorina, two Associate Professors, Prof. Francesca D’Addio and Prof. Moufida Ben Nasr, an Assistant Professor and lab manager Dr. Cristian Loretelli, four Researchers Dr. Vera Usuelli, Dr. Emma Assi, Dr. Alessandra Petrelli and Dr. Loredana Bucciarelli, three young post-docs and one PhD student.
