PEDIATRIC CLINICAL

RESEARCH CENTER

 

PEDIATRIC CLINICAL RESEARCH CENTER

 

ROMEO AND ENRICA INVERNIZZI

WELCOME

The Pediatric Research Center Romeo and Enrica Invernizzi was born from the collaboration of the University of Milan with the Fondazione Invernizzi and the Sacco-Fatebenefratelli Hospital, to constitute a pole of excellence that focuses on the development of personalized medicine for pediatric diseases.

The Center offers 700 square meters of laboratories equipped with the most modern instruments for the study of cellular, molecular and structural biology in order to create an integrated scientific network and a state-of-the-art pole for basic, translational and clinical research.

GIAN VINCENZO ZUCCOTTI

The Scientific Research Committee is coordinated by Professor Gian Vincenzo Zuccotti,  Dean of Faculty of Medicine & Surgery - University of Milan , Director of Department of Pediatrics, Ospedale dei Bambini  V. Buzzi.

The Center develops the following research topics: type 1 diabetes, pharmacokinetics / pharmacogenetics and regenerative medicine, bacterial genomics, electron cryo-microscopy and nanomedicine.

 

Romeo and Enrica Invernizzi Foundation

The Romeo and Enrica Invernizzi Foundation was born at the beginning of the nineties by the will of the Cavaliere del Lavoro Romeo Invernizzi, one of the most brilliant and innovative businessman in the Italian food industry, and of his wife Enrica Pessina, a constant presence in Milan's social life, to provide give a point of reference for research in Lombardia and promote, through the knowledge, the progress and the welfare of society.

The Foundation has always supported initiatives in the field of Economics, Food Science, Medicine and Surgery.

Collaboration with three major Milan Universities (University of Milan La Statale, Catholic University and University Bocconi) has in recent years leaded to fund several research projects and encouraging research activity of international significance.

To find out more about the Invernizzi Foundation, see the brochure.

FIORINA GROUP

THE INTERNATIONAL CENTER FOR TYPE 1 DIABETES

PAOLO FIORINA

Guided by Professor Paolo Fiorina, this team intends to explore lines of  research focused on the treatment of type 1 diabetes and its complications, prevention strategies and new cell replacement therapies and application of new technologies.

The goal is to become a national and international Center of Excellence and Reference for Clinical and Experimental Studies for type 1 diabetes.

The team consists of Prof. Fiorina and two researchers, Dr. Francesca D'Addio and Dr. Moufida Ben Nasr, a Senior Scientist / Lab Manager Dr. Cristian Loretelli and five young post-doc fellows.  

The Fiorina Group's expertise consists mainly in functional phenotypic and immunological characterization within immune mediated diseases such as type 1 diabetes (flow cytometry, Elispot, Cytokines profiling, T-helper cell generation), study of new disease pathways and physiopathology of beta cells and pancreatic neogenic niche (RT-PCR, Digital PCR, immunofluorescence, confocal microscopy).

DI GIULIO GROUP

REGENERATIVE MEDICINE AND PEDIATRIC PHARMACOLOGY LABORATORY

ANNA MARIA DI GIULIO

Led by Professor Anna Maria Di Giulio, the team focuses its research interests on the developing of innovative research strategies in the field of Regenerative Medicine, Pharmacokinetic and Pharmacogenetics applied to pediatric diseases, primarily those that affect the central nervous system.

The group has a strong translational drive being involved in the development of both pre-clinical and clinical trial studies in humans on the traumatic paraplegia, Parkinson’s disease, ALS and diabetic neuropathy.

The team currently comprises Professor Anna Maria Di Giulio, an associate professor, Dr. Elena Lesma, a senior scientist, Dr. Stephana Carelli, a post-doc/lab manager, PhD students and fellows.

The Di Giulio’s group has a strong experience in the development of novel procedures in the field of stem cells biology, such as isolation of stem cells from different sources, their functional and phenotypic characterization (FACS analysis, cytokines profiling, differentiation, and investigation of specific molecular pathways).

The group has also strong expertise in both the physiopathology of neurodegenerative diseases (ALS, Parkinson, spinal cord injury, peripheral neuropathies) and the developing cell therapy strategies: set up of procedures for stem cells manipulation, transplantation and investigation of their mechanisms of action (histology, RT-PCR, Digital PCR, immunofluorescence, confocal microscopy, western blotting).

BANDI GROUP

PLATFORM FOR GENOMIC EPIDEMIOLOGY AND EXPERIMENTAL MICROBIOLOGY

CLAUDIO BANDI

The group led by Prof. Claudio Bandi focuses on two main topics, the infections caused by multi-drug resistant bacteria, and some neglected parasitic and vector-borne diseases, with a particular attention for infections of pediatric interest.

Two microbiologists, two bioinformaticians, two parasitologists, a molecular biologist, and a mathematician compose this multidisciplinary team.

The group is setting up an innovative platform for genomic epidemiology (UNIMI Sky Net), based on biomolecular, computational and genomic tools, which will help to detect and control epidemic outbreaks, with a particular focus on nosocomial infections.

Other projects have the objectives of developing a novel bacterial vaccine vehicle, of discovering microbial proteins with antigenic and immune-modulatory properties, of determining the role of the microbiota in immune-mediated pathologies in children.

 

The group can provide full support to the characterization of microorganisms and to epidemiological reconstructions, through the application of genomic, bioinformatics and computational tools. The know-how of the group allows to: conduct genomic comparisons and phylogenomic analyses; investigate the microbiota, both through amplicon-based and shotgun metagenomics approaches; produce and characterize recombinant proteins.

The group relies on two NGS machines (Illumina NextSq and MiSeq).

BOLOGNESI GROUP

CRYO EM LABORATORY

GRUPPO BANDI

14 Giugno      |      Posted by Admin     |     Breve descrizione gruppo Bandi   |     3 Comments

MARTINO BOLOGNESI

The cryo-EM research group, founded in 2017, aims at the application of single particle cryo-electron microscopy methods to the study of proteins, nucleic acids, and their complexes. Present components of the group are Prof. Martino Bolognesi and Dr. Paolo Swuec. Internal research lines will be pursued in the search and structural analyses of molecular targets suitable for drug design approaches.

The group will also support a service activity for the academic and industrial communities.

User access to the FEI Talos Arctica cryo-microscope will be possible through a competitive application system

The cryo-electron microscopy lab provides expertise, methods and experimental approaches in the field of structural biology.

Through biochemical, biophysical and single particle cryo EM approaches, we tackle the three-dimensional structures of proteins and nucleic acids, particularly when these are assembled in large multicomponent complexes.

Our methods focus on targets that are relevant for biomed applications; however, single particle cryo EM can approach almost any macromolecular system that can be isolated and purified in microgram amounts.

CARUGO - POMPILIO GROUP

RESEARCH CENTER FOR CARDIOMIOPATIES (CERCA)

The applied research activity of CERCA aims to understand pathogenesis and innovative diagnostic and therapeutic strategies for cardiovascular diseases, in particular heart failure of genetic or ischemic origin (with specific focus on regenerative medicine), for which conventional therapies are either not sufficient or not available. The team is composed by Prof. Pompilio, Prof. Carugo, five physicians, one geneticist, one research staff, seven post-docs, two laboratory technicians and a clinical research assistant.

STEFANO CARUGO | GIULIO POMPILIO

GRUPPO BANDI

14 Giugno      |      Posted by Admin     |     Breve descrizione gruppo Bandi   |     3 Comments

Besides a solid experience in the diagnosis and treatment of heart diseases and cardiomyopathies, the group is involved in clinical and translational research.

CORSI GROUP

NANOMEDICINE UNIT

FABIO CORSI

Leaded by Professor Fabio Corsi, Nanomedicine's team is devoted to the development of nanotechnology agents for the diagnosis and treatment of several diseases, focusing mainly on breast cancer and intestinal bowel disease.

Their aim is to exploit nanotechnologies for the development of new diagnostic methods or new targeted therapeutic agents.

The team is constituted by Prof. Corsi, the senior scientist Dr. Serena Mazzucchelli, the post-doctoral fellow Dr. Marta Truffi, the electron microscope technician, Mr. Raffaele Allevi and some young fellows.

GRUPPO BANDI

14 Giugno      |      Posted by Admin     |     Breve descrizione gruppo Bandi   |     3 Comments

The expertise of the Nanomedicine team is based on the characterization of the interactions between nanocomposite and biological system and on their possible therapeutic efficacy.

The group also has a good know-how in drug formulation in protein nanocages protein compounds and in the morphological characterization of organic and inorganic nanoparticles.

ONE SPECIAL THANKS

FOR OUR PARTNERS

Fondazione Amici dell' Infanzia Onlus

NEWS

NEWS AND EVENTS FROM THE CENTER

 28 - 29 SEPTEMBER 2018

 12 - 14 SEPTEMBER 2018

DONATION TO THE CENTER

DONATION TO THE CENTER GROUPS

 

You can choose

 

Children are our future and pediatric diseases often require a personalized medicine, but research has high costs to be able to act on each one individually. Our Center wants to offer an answer to all those who need it, both families and children, to not lose hope and to offer a new opportunity and a new therap. With your help we can do it.

 

You can make your donation by bank transfer to the following references or via Paypal.

 

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BORGHI LEONARDO - BRESAOLA LUCIA - FAMIGLIA DRAGONI - SGARBI DANIELA - FAMIGLIA TAIBBI - IPPOLITO GIULIA

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                                                        Info Contact: PEDIATRIC CLINICAL RESEARCH CENTER ROMEO AND ENRICA INVERNIZZI  HOSPITAL L. SACCO BUILDING 62

                                                  Street Giovanni Battista Grassi, 74, 20157 Milano | Phone: 02/50319823 | Website: Crcpediatrico.org

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BORGHI LEONARDO - BRESAOLA LUCIA - FAMIGLIA DRAGONI - SGARBI DANIELA - FAMIGLIA TAIBBI - IPPOLITO GIULIA